Adipotide 2mg jakisoni

Adipotide (aka FTPP kapena proapototic peptide) amapha maselo amafuta, osavuta komanso osavuta, poyang'ana momwe magazi amayendera.Chochititsa chidwi n'chakuti, adipotide amatha kuzindikira mitsempha ya magazi m'maselo a mafuta kuchokera m'mitsempha yamagazi m'thupi lonse ndipo motero amasankha kwambiri.Kafukufuku wa nyani akuwonetsa kuti adipotide sikuti imangochepetsa thupi, imathandizira chidwi cha insulin ndikuchotsa zina mwazotsatira za mtundu wa 2 shuga.

Kagwiritsidwe Ntchito Ka Zogulitsa: ZOTHANDIZA ZINTHU ZOFUNIKA NGATI CHEMICAL YOPHUNZITSIRA POKHA.Kutchulidwa kumeneku kumalola kugwiritsa ntchito mankhwala ofufuza mosamalitsa kuyesa kwa in vitro ndi kuyesa kwa labotale kokha.Zonse zomwe zilipo pa webusaitiyi ndi za maphunziro okha.Kulowetsa thupi lamtundu uliwonse mwa anthu kapena nyama ndikoletsedwa ndi lamulo.Izi ziyenera kuyendetsedwa ndi akatswiri omwe ali ndi chilolezo, oyenerera.Izi si mankhwala, chakudya, kapena zodzoladzola ndipo sizingatchulidwe molakwika, kugwiritsidwa ntchito molakwika kapena kusokonezedwa ngati mankhwala, chakudya kapena zodzola.

Sequence: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys—Gly-Gly–(Lys-Leu-Ala-Lys-Leu-Ala-Ls)2
Molecular formula: C152H252N44O42
Kulemera kwa Maselo: 2611.41 g/mol

Adipotide idapangidwa ndikuyikidwa m'mayesero azachipatala a gawo I mu 2011 kuti afufuze momwe amatha kupha maselo amafuta.Mayeso a anyani a rhesus adawonetsa kuti adipotide imayambitsa apoptosis m'mitsempha yamafuta oyera adipose (mafuta).Popanda magazi, maselo amafuta amangofa.Zotsatira zake zinali kuchepa thupi mwachangu, kuchepa mwachangu kwa index ya misa ya thupi (BMI), komanso kuwongolera mawonekedwe a insulin.Chochititsa chidwi n'chakuti, chithandizo cha adipotide ndi kutaya mafuta kotsatira sikungowonjezera kulemera kwake, koma kwenikweni kunathandizira kusintha kwa khalidwe la kudya.Anyani omwe anawonda ndi adipotide adawonetsanso kuchepa kwa chakudya[1].

A. Maperesenti ochepetsa thupi m'magulu owongolera (buluu) motsutsana ndi omwe amathandizidwa ndi adipotide (milingo iwiri yosiyana, yowonetsedwa mofiira)
B. Kuchepetsa kwa BMI (kuwongolera motsutsana ndi chithandizo)

A. Imawonetsa kusintha kwa insulini yofunikira (malo omwe ali pansi pa curve) pamagulu othandizidwa (ofiira) ndi owongolera (abuluu).AUC idawerengedwa kuchokera ku mayeso a IVGTT.
B. Imawonetsa index ya insulinogenic yamagulu asanayambe komanso atatha mankhwala (ofiira) ndi owongolera (buluu).Magulu othandizidwa akuwonetsa kuchepa kwakukulu kwa katulutsidwe ka insulin.
C. Kusintha kwa ma biscuit mumagulu ochiritsidwa (ofiira) ndi olamulira (buluu).

Kulunjika kwa adipotide m'mitsempha yamagazi yomwe imatumikira ma cell amafuta kumatha kukhala mkhalapakati ndi cholandilira mapuloteni chotchedwa prohibitin.Prohibitin ndi mapuloteni a membrane omwe amapezeka m'mitsempha yamagazi yomwe imagwira mafuta oyera komanso m'maselo a khansa.Zawonetsedwa kuti adipotide amalumikizana ndi puloteni iyi[2].Ngati zikuwonekeratu kuti prohibitin imapezeka kokha m'mitsempha yamafuta ndi minofu ya khansa, ndiye kuti kuyesa kwa adipotide kudzakhala ndi udindo wozindikira chandamale chamafuta omwe angagwiritsidwe ntchito osati pazifukwa zochiritsira, komanso zowunikira.