SR9009 mapiritsi 100 mapiritsi/botolo

Dzina lazogulitsa:Mtengo wa SR9009

Kutalikirana: 10 mg/piritsi 100 mapiritsi/botolo

Mtengo: $ 80 / botolo

MOQ: botolo la 1

Lab: LianFu Bio

Kutanthauzira kwazinthu

SR9009, ndi REV-ERBagonist, kumawonjezera kuponderezedwa kovomerezeka kwa majini oyendetsedwa ndi REV-ERBα / ERBβ (IC50: 670 / 800 nM).Kupyolera mu kutsegula kwa REV-ERB, SR9009 ikhoza kuchepetsa zochitika za circadian locomotor panthawi yamdima ndikusintha mawonekedwe amtundu wa core clock mu hypothalami ya mbewa.Mawonekedwe a circadian amitundu yambiri yama metabolic m'chiwindi, chigoba, ndi minofu ya adipose adasinthidwanso mu mbewa zomwe zimawonekera ku SR9009, zomwe zidapangitsa kuti ndalama ziwonjezeke.

SR9009 (100 mg/kg, ip, bid, kwa masiku 30) akhozakuchepetsa mafutandipo modziwikakuchepetsa dyslipidemiandihyperglycemia.