Medical ufa waiwisi wa MK-677
Mafotokozedwe Akatundu
| Nambala ya CAS | 159752-10-0 |
| Maonekedwe | ufa |
| Mayina a Chemical | Ibutamoren;CHEMBL13817;S1151_Selleck;UNII-GJ0EGN38UL;159634-47-6;MK-0677; |
| Molecular Formula | Chithunzi cha C27H36N4O5S |
| Kulemera kwa Maselo | 528.66354 g/mol |
Mtengo wa MK-677
MK-677, yomwe imatchedwanso Ibutamoren, ndi SARM yosagwiritsa ntchito steroidal oral (selective androgen receptor modulator) yomwe imagwiritsidwa ntchito kwambiri pofuna kuonjezera kukula kwa hormone m'thupi.Zomwe zimagwiritsidwa ntchito mu MK-677 ndi mankhwala omwe amadziwika kuti Ibutamoren Mesylate.
Ibutamoren Mesylate imagwira ntchito poyambitsa ghrelin receptor, yomwe ili ndi udindo wolimbikitsa kupanga kukula kwa hormone.Ndi agonist yosankha kwambiri, kutanthauza kuti imayang'ana makamaka ndikuyambitsa ghrelin receptor, zomwe zimapangitsa kuti katulutsidwe ka kukula kwa hormone.
Kafukufuku wasonyeza kuti MK-677 ikhoza kuonjezera kukula kwa mahomoni ndi maulendo angapo, zomwe zimapangitsa kuti minofu ikhale yabwino, kuchepetsa mafuta a thupi, kuwonjezereka kwa mafupa, komanso kugona bwino.Amaganiziridwanso kuti ali ndi zotsutsana ndi ukalamba, monga momwe kukula kwa mahomoni okwera kumayenderana ndi kuchepa kwa ukalamba ndi kuwonjezereka kwa moyo wautali.
Wonjezerani mlingo wa kukula kwa hormone.Hormone ya kukula kwapakamwa yopanda peptide imathandizira kutulutsidwa kwa GH kudzera mu zolandilira mu pituitary gland ndi hypothalamus, zomwe ndizosiyana ndi kukula kwa timadzi totulutsa timadzi tambiri.MK-677 ndi katulutsidwe kogwira mtima kamene kakukula m'kamwa, komwe kamatengera zotsatira za GH polimbikitsa mahomoni amkati.Zasonyezedwa kuti ziwonjezeke kumasulidwa ndi kutulutsa kukula kosalekeza kwa mahomoni a plasma, kuphatikizapo kukula kwa hormone ndi IGF-1, koma sikukhudza milingo ya Cortisol.
Mofanana ndi mankhwala atsopano kapena zowonjezera, ndikofunika kukaonana ndi katswiri wodziwa zaumoyo musanagwiritse ntchito MK-677.
Pomaliza, MK-677 ndiyowonjezera yomwe ingakhale yothandiza pakukulitsa kuchuluka kwa timadzi tating'onoting'ono komanso kulimbikitsa thanzi labwino komanso thanzi.Komabe, kafukufuku wochulukirapo akufunika kuti adziwe chitetezo chake chanthawi yayitali komanso mphamvu zake, komanso kumvetsetsa bwino momwe zimakhudzira thupi la munthu.Monga nthawi zonse, ndikofunika kusamala mukamagwiritsa ntchito zowonjezera zatsopano komanso kukaonana ndi katswiri wa zaumoyo musanayambe mankhwala atsopano.
