Nkhaniyi ikuthandizani kusankha yomwe mungakonde poyankha mafunso otsatirawa:
1.Kodi pali kusiyana kotani pakati pa tirzepatide ndi retatrutide?
2.Kodi ubwino wa tirzepatide ndi chiyani?
3.Kodi ubwino wa retatrutide ndi chiyani?
4.Kuyerekeza Ubwino wa Retatrutide ndi Tirzepatide
Kodi pali kusiyana kotani pakati pa tirzepatide ndi retatrutide?
Kusiyana kwakukulu pakati pa tirzepatide ndi retatrutide kuli mu kapangidwe kawo.Tirzepatide ndi kuphatikiza kwa zigawo zitatu zogwira ntchito - liraglutide, glucagon-ngati peptide-1 agonist (GLP-1);analogue ya oxyntomodulin;ndi analogue ya GLP-2.Retarutide, kumbali ina, imapangidwa ndi chigawo chimodzi chogwira ntchito - exenatide, china GLP-1 chowonetsedwa kwambiri mu kapamba.Mankhwala onsewa amagwiritsidwa ntchito pochiza matenda amtundu wa 2 powonjezera kupanga kwa insulin komanso kutsitsa shuga m'magazi.Komabe, retarutide yasonyezedwanso kuchepetsa chilakolako chofuna kudya bwino kuposa tirzepatide yokha chifukwa cha zotsatira zake pa mahomoni okhudzidwa ndi njala ndi kukhuta.Momwemo, itha kugwiritsidwa ntchito ngati gawo la njira yophatikizira yowongolera kulemera kwa anthu omwe ali ndi matenda a shuga omwe ali onenepa kwambiri kapena onenepa kwambiri.
Kodi ubwino wa tirzepatide ndi chiyani?
①Kuwongolera kwa glycemic control ndi ma A1C, zomwe zimatsogolera ku thanzi labwino
Tirzepatide, glucagon-ngati peptide 1 receptor agonist ndi GLP-1/glucose-dependent insulinotropic polypeptide (GIP) dual agonist, ndi njira yatsopano yothandizira matenda amtundu wa 2.Zapezeka kuti ndizothandiza kwambiri kuposa retatrutide pakuwongolera kuwongolera kwa glycemic ndi ma A1C.M'mayesero achipatala, tirzepatide inagwirizanitsidwa ndi kuchepetsa kwakukulu kwa ma A1C pa masabata a 12 poyerekeza ndi retatrutide (-2.3% vs -1.8%), zomwe zimapangitsa kuti pakhale zotsatira zabwino za thanzi kwa odwala.
②Kuchepetsa chiopsezo cha zochitika zamtima monga matenda a mtima ndi sitiroko
Tirzepatide imapereka maubwino angapo omwe angakhalepo kwa anthu omwe ali pachiwopsezo cha zochitika zamtima monga matenda amtima komanso sitiroko.Kafukufuku wa 2019 wofalitsidwa mu nyuzipepala ya The Lancet adapeza kuti anthu omwe amamwa tirzepatide anali ndi chiopsezo chochepa kwambiri cha zochitika zazikulu zamtima (MACE) poyerekeza ndi omwe amatenga retatrutide.Izi zinaphatikizapo kuchepa kwa 35% kwa MACE poyerekeza ndi retatrutide, zomwe sizinawonetse kusiyana kwakukulu pazochitika za chiopsezo cha mtima.Pakafukufukuyu, ofufuzawo adawona kuti odwala omwe amamwa tirzepatide adakumana ndi matenda otsika a mitsempha yamagazi, infarction ya myocardial, kulephera kwamtima komanso sitiroko kuposa omwe ali mgulu la retatrutide.Kuphatikiza apo, omwe adatenga tirzepatide adanenanso kuti kuchuluka kwa shuga m'magazi kumachepa komanso kuchepa thupi poyerekeza ndi omwe amatenga retatrutide.Pomaliza, ndikofunikira kudziwa kuti anthu omwe amatenga tirzepatide sanatetezedwe kokha ku MACE komanso anali ndi kuchepa kwa milingo ya HbA1c (chizindikiro cha kuwonongeka kwa shuga kwa nthawi yayitali) komanso kuchuluka kwamafuta amthupi poyerekeza ndi magawo oyambira.Pamapeto pake, zotsatirazi zikuwonetsa kuthekera kwa tirzepatide kuchepetsa zochitika zamtima zomwe zimakhudzana ndi matenda a shuga a 2 ndikupereka maubwino owonjezera okhudzana ndi kapangidwe ka thupi.
Kutsika kwa thupi poyerekeza ndi retatrutide, zomwe zingathandize kuchepetsa chiopsezo cha matenda okhudzana ndi kunenepa kwambiri
Tirzepatide ili ndi maubwino angapo poyerekeza ndi retatrutide, makamaka pankhani ya kulemera kwa thupi.Kafukufuku wapeza kuti tirzepatide ikhoza kubweretsa kuchepetsa kwambiri kulemera kwa thupi kusiyana ndi retatrutide kwa nthawi yaitali.Izi zitha kuchitika chifukwa chakutha kwake kulimbikitsa ntchito zolandilira za GLP-1 ndikulimbikitsa kukhuta.Kuphatikiza apo, tirzepatide yapezeka kuti imachepetsa mafuta am'mimba bwino kuposa retatrutide, zomwe zingathandize kuchepetsa chiopsezo cha matenda a shuga, matenda amtima, ndi matenda ena okhudzana ndi kunenepa kwambiri.Kuphatikiza apo, tirzepatide yawonetsedwa kuti imachepetsa shuga wamagazi bwino kwambiri kuposa retatrutide.Zotsatira izi zikaphatikizidwa zimatha kusintha zotsatira zathanzi zokhudzana ndi kunenepa kwambiri komanso kusokonezeka kwa metabolic.
③Kuwonjezeka kwamphamvu kwamphamvu chifukwa cha kusintha kwa glucose metabolism
Ubwino wina waukulu wotengera tirzepatide ndikutha kukulitsa mphamvu chifukwa chakusintha kwa glucose metabolism.Izi ndichifukwa choti ma GLP1 receptor agonists amakonda ntchito ya tirzepatide polimbikitsa kutulutsidwa kwa insulin poyankha kuchuluka kwa shuga m'magazi.Powonjezera kupanga kwa insulini ndikuwongolera kagayidwe ka glucose, thupi limatha kugwiritsa ntchito shuga wambiri ngati mafuta ndipo izi zitha kupangitsa kuti mphamvu ziwonjezeke.Kuphatikiza apo, ma GLP1 receptor agonists amathanso kuchepetsa chilakolako cha chakudya, zomwe zimabweretsa kuchepa kwa zilakolako za chakudya komanso kuyendetsa bwino kulemera.
Kodi ubwino wa retatrutide ndi chiyani?
Retatrutidendi jakisoni wanthawi yayitali omwe amagwiritsidwa ntchito pochiza matenda amtundu wa 2.Zavomerezedwa ndi US Food and Drug Administration (FDA) pachifukwa ichi.Ubwino wa retatrutide ndi wochuluka, ndikupangitsa kuti ikhale njira yabwino pakati pamankhwala ena a shuga.
Pongoyambira, retatrutide imagwira ntchito mwachangu ikangobayidwa ndipo zotsatira zake zimatha kumveka mkati mwa maola 24 otsogolera.Izi zimapangitsa kuti ikhale yothamanga kwambiri kuposa majekeseni ena omwe amakhala nthawi yayitali monga tirzepatide, yomwe imatha kutenga milungu ingapo kuti zotsatira zowoneka bwino ziwonekere m'magazi a shuga.
Kuonjezera apo, kafukufuku wasonyeza kuti retatrutide ndi yothandiza kuchepetsa ma A1C kwa anthu omwe ali ndi matenda a shuga a mtundu wa 2 pamene atengedwa pamodzi ndi zakudya ndi kusintha kwa masewera olimbitsa thupi.Mayesero azachipatala awonetsanso kuti retatrutide imathandizira kuchepetsa kusala kudya kwa glucose komanso kuwongolera kwathunthu kwa glycemic mwa ogwiritsa ntchito poyerekeza ndi placebo.Nthawi zina, anthu omwe sanapindulepo ndi mankhwala a shuga a m'kamwa akhala ndi zotsatira zabwino ndi chithandizo cha retatrutide.
Pomaliza, chimodzi mwazabwino zazikulu za retatrutide ndi njira yake yosavuta yoyendetsera;pamafunika jekeseni imodzi yokha pa sabata m'malo mwa jakisoni angapo tsiku lililonse monga mankhwala ena ambiri a shuga.Izi zitha kupangitsa kusamalira matenda anu a shuga kukhala kosavuta komanso kumathandizira kuti odwala asamatsatire dongosolo lamankhwala pakapita nthawi.
Kuyerekeza Ubwino wa Retatrutide ndi Tirzepatide
Zikafika pakuchita bwino, retatrutide yawonetsedwa kuti imachepetsa kuchuluka kwa HbA1c ndi 1.9-2.4%, poyerekeza ndi Tirzepatide yomwe imachepetsa kuchuluka kwa HbA1c ndi 1.5-2%.Mankhwala onsewa amakhalanso ndi zotsatira zofanana, monga nseru ndi mutu.Komabe, anthu ena angapeze kuti amakumana ndi zotsatira zochepa ndi Retatrutide kusiyana ndi Tirzepatide chifukwa cha kuchepa kwake kwa mlingo.
Kumbali ya chitetezo, retarutide imalekerera bwino ikagwiritsidwa ntchito pa Mlingo wovomerezeka ndipo sikuwonjezera chiopsezo cha hypoglycemia kapena kukulitsa kunenepa monga momwe machiritso ena a shuga angathandizire.Kumbali inayi, Tirzepatide ili ndi chiwopsezo chachikulu cha momwe jakisoni amachitira chifukwa chakukula kwake.Kuphatikiza apo, ngati amwedwa mopitilira muyeso amatha kuyambitsa hypoglycemia yayikulu komanso kunenepa kwambiri.
Mwachidule, onse a retarutide ndi tirzepatide ndi njira zabwino zothetsera matenda a shuga a 2 koma imodzi ikhoza kukhala yoyenera kwa odwala ena malinga ndi zosowa zawo.Retarutide imapereka mphamvu yabwino yokhala ndi zotsatirapo zochepa komanso kukhala otetezeka pamilingo yovomerezeka;komabe, Tirzepatide ikhoza kupereka kuchepetsa kwakukulu kwa milingo ya HbA1c komanso imatha kukhala ndi chiopsezo chachikulu cha zotsatira zoyipa ngati sichigwiritsidwa ntchito moyenera.Pamapeto pake, ndikofunikira kukaonana ndi dokotala kuti musankhe chithandizo chomwe chili choyenera kwa inu malinga ndi momwe mulili komanso zolinga zanu zaumoyo.
Yambitsani mankhwala anu a tirzepatide ndi semaglutide ku LianFu
Nthawi yotumiza: Mar-18-2024