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mankhwala

Sarms Powder Yaiwisi S4/andarine

Kufotokozera mwachidule:

Dzina: S4/andarine

CAS : 401900-40-1

Molecular formula: C19H18F3N3O6

Mtengo: 3200usd/kg

Maonekedwe: ufa woyera


Tsatanetsatane wa Zamalonda

Kodi S-4 (Andrarine) ndi chiyani

S-4, yogulitsidwa ngatiandarine, ndi orally bioavailable, non-steroidal selective androgen receptor modulator (SARM).Andarine ndi agonist pang'ono wa androgen receptor.

S-4 monga ma SARMS ena adapangidwa kumayambiriro kwa zaka za m'ma 2000, pofuna kuthana ndi malire a pharmacologic ndi pharmacokinetic a steroidal androgen receptor agonists (ie, testosterone ndi DHT), omwe adziwa mayanjano ndi chiwindi ndi matenda a mtima.

Compound S-4 idagwiritsidwa ntchito m'maphunziro a nyama koma idasiyidwa mayeso achipatala a anthu a Phase I asanachitike, chifukwa cha kuwonongeka kwa mawonekedwe.Zotsatirazi zimachitika pamene molekyulu ya S-4 imamangiriza ku zolandilira m'maso;Kumangirirako kumangika mwaukali, m'pamenenso pali kusapeza bwino komwe kumakhalapo.Zosokoneza zowoneka zidapezeka kuti ndizofala kwambiri, chifukwa cha machitidwe apadera amakanika, pamankhwala omwe mayeserowo adasiyidwa.

Zimatheka BwanjiS4Ntchito ya Andarine

Imodzi mwa njira zomwe zaperekedwaS4, ndikuti imaletsa kumangirira kwa DHT.Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone kapena stanolone) ndi mahomoni ogonana a androgen.Zogwirizana ndi testosterone, DHT ndi yamphamvu kwambiri ngati agonist wa androgen receptor.

S-4 ili ndi mgwirizano wapamwamba wa androgen receptor (AR).Kafukufuku wasonyeza kuti S-4 ndi yochepa kwambiri komanso yothandiza kuposa testosterone propionate (TP) mu ntchito ya androgenic, koma ntchito yawo ya anabolic inali yofanana kapena yaikulu kuposa ya TP.

S-4 ndi agonist wathunthu wa androgen receptor mu minofu ya minofu, komanso agonist pang'ono mu prostate.Choncho, S-4 imalimbikitsa kukula kwa minofu, koma sangathe kusunga kukula kwa prostate.Testosterone imapangitsa kukula kwa minofu ndi prostate mofanana.S-4 imayambitsa mphamvu ya luteinizing hormone (LH) kapena follicle stimulating hormone kuponderezedwa.

 

S-4 (andarine) Ubwino

Ngakhale kuti kafukufuku wambiri wachitika, kafukufuku wambiri akupitirirabe komanso kumayambiriro kwa chitukuko.Kukula kwa SARMS kwa ntchito zachipatala ndi zochizira monga njira ina ya androgen, ikulonjeza kutengera chidziwitso cha preclinical.

Mosiyana ndi ma anabolic steroids, omwe amamangiriza ku androgen zolandilira m'magulu ambiri m'thupi lonse, ma SARM amtundu uliwonse amamangirira ma androgen receptors muzinthu zina, koma osati mwa ena.Komabe, akuwonetsabe zotsatira za androgenic ndi anabolic.

SARMS si anabolic steroids;m'malo mwake, ndi ma ligands opangidwa omwe amamangiriza ku ma androgen receptors.Kutengera kapangidwe kawo ka maselo, amakhala ngati agonists, agonists pang'ono, ndi otsutsa.Choncho ndi njira yosankha, kuti SARMS isinthe kapena kugwirizanitsa otsogolera ndi zolemba zolembera kapena kuwonetsa mapuloteni a cascade kuti apititse patsogolo ntchito ya anabolic.

Kafukufuku wawonetsa kuti S-4 ndi agonist wathunthu wa androgen receptor mu minofu ya minofu, komanso agonist pang'ono mu prostate, zomwe zimapangitsa kukhala woyenera kukhala m'malo mwa steroidal androgen receptor agonists (ie, testosterone ndi DHT), chifukwa cha zotsatira zoyipa pa chiwindi, mtima, ndi chonde.

Tiyenera kuzindikira, kuti ngakhale ma SARMS ngati S4 amachulukitsa ntchito ya androgen, siwoyenera kuchitapo kanthu pamankhwala obwezeretsa mahomoni, chifukwa samatulutsa aromatize mu Estrogen.


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