Semaglutide ndi polypeptide yomwe madokotala amalembera kuti azichiza matenda amtundu wa 2.A FDA avomereza kugwiritsidwa ntchito kwa Novo Nordisk's Ozempic ndi Rybelsus ngati jekeseni kamodzi pamlungu kapena ngati piritsi, motsatana.Jakisoni wa semaglutide kamodzi pa sabata wokhala ndi dzina la Wegovy wavomerezedwa posachedwa ngati chithandizo chochepetsa thupi.
Kafukufuku watsopano woperekedwa ku European Congress on Obesity ya chaka chino (ECO2023, Dublin, 17-20 May) akuwonetsa kuti kunenepa kwambiri mankhwala semaglutide ndi othandiza pakuchepetsa thupi mu multicenter, 1-year-long real-world world study.Phunziroli ndi Dr Andres Acosta ndi Dr Wissam Ghusn, Precision Medicine for Obesity Programme ku Mayo Clinic, Rochester, MN, USA ndi anzawo.
Semaglutide, glucagon-like peptide-1 (GLP-1) receptor agonist, ndi mankhwala omwe avomerezedwa posachedwa ndi FDA oletsa kunenepa kwambiri.Zawonetsa zotsatira zazikulu zochepetsera thupi m'mayesero achipatala a nthawi yayitali osasinthika komanso maphunziro anthawi yochepa kwenikweni.Komabe, ndizochepa zomwe zimadziwika pakuchepetsa thupi komanso zotsatira za kagayidwe kachakudya m'maphunziro apakati pazaka zenizeni padziko lapansi.Mu phunziro ili, olembawo adawunika zotsatira zolemetsa zomwe zimagwirizanitsidwa ndi semaglutide kwa odwala omwe ali ndi kunenepa kwambiri komanso kunenepa kwambiri komanso opanda mtundu wa 2 shuga (T2DM) pakutsatira kwa chaka chimodzi.
Iwo adachita kafukufuku, multicentre (Mayo Clinic Hospitals: Minnesota, Arizona, ndi Florida) zosonkhanitsa deta za kugwiritsa ntchito semaglutide pofuna kuchiza kunenepa kwambiri.Anaphatikizapo odwala omwe ali ndi chiwerengero cha thupi (BMI) ≥27 kg / m2 (olemera kwambiri ndi magulu onse apamwamba a BMI) omwe amaperekedwa mlungu uliwonse jekeseni wa semaglutide subcutaneous (mlingo 0.25, 0.5, 1, 1.7, 2, 2.4mg; komabe ambiri anali pa mlingo waukulu 2.4 mg).Sanaphatikizepo odwala omwe amamwa mankhwala ena ochepetsa kunenepa, omwe adachitidwapo opaleshoni ya kunenepa kwambiri, omwe ali ndi khansa, ndi omwe anali ndi pakati.
Chomaliza chachikulu chinali kuchuluka kwa kulemera kwa thupi (TBWL%) pa 1 chaka.Mfundo zomaliza zachiwiri zimaphatikizapo kuchuluka kwa odwala omwe akupeza ≥5%, ≥10%, ≥15%, ndi ≥20% TBWL%, kusintha kwa kagayidwe kachakudya ndi mtima wamtima (kuthamanga kwa magazi, HbA1c [glycated hemoglobin, muyeso wa kuwongolera shuga m'magazi], kusala shuga ndi mafuta a m'magazi), TBWL% ya odwala omwe ali ndi T2DM komanso opanda T2DM, komanso kuchuluka kwa zotsatira zoyipa m'chaka choyamba chamankhwala.
Okwana 305 odwala anaphatikizidwa mu kusanthula (73% akazi, zikutanthauza zaka 49 zaka, 92% woyera, zikutanthauza BMI 41, 26% ndi T2DM).Makhalidwe oyambira ndi tsatanetsatane woyendera kasamalidwe ka kulemera akufotokozedwa mu Table 1 mwachidule.Pagulu lonselo, tanthauzo la TBWL% linali 13.4% pa chaka cha 1 (kwa odwala 110 omwe anali ndi deta yolemera pa chaka cha 1).Odwala omwe ali ndi T2DM anali ndi TBWL yochepa% ya 10.1% kwa odwala 45 a 110 omwe ali ndi deta pa chaka cha 1, poyerekeza ndi omwe alibe T2DM ya 16.7% kwa 65 mwa odwala 110 omwe ali ndi deta pa chaka chimodzi.
Chiwerengero cha odwala omwe anataya oposa 5% a kulemera kwa thupi lawo anali 82%, oposa 10% anali 65%, oposa 15% anali 41%, ndipo oposa 20% anali 21% pa 1 chaka.Chithandizo cha Semaglutide chinachepetsanso kwambiri kuthamanga kwa magazi kwa systolic ndi diastolic ndi 6.8 / 2.5 mmHg;cholesterol chonse ndi 10.2 mg/dL;LDL ya 5.1 mg / dL;ndi triglycerides wa 17.6 mg/dL.Theka la odwala adakumana ndi zovuta zokhudzana ndi kugwiritsa ntchito mankhwala (154/305) pomwe ambiri amanenedwa kukhala nseru (38%) ndi kutsekula m'mimba (9%) (Chithunzi 1D).Zotsatira zake zinali zochepa kwambiri zomwe sizimakhudza moyo wabwino koma muzochitika za 16 zidapangitsa kuti asiye mankhwala.
Olembawo anamaliza kuti: "Semaglutide inagwirizanitsidwa ndi kuchepa kwakukulu kwa kulemera kwa thupi ndi kusintha kwa kagayidwe kachakudya pa chaka cha 1 mu kafukufuku wapadziko lonse lapansi wamitundu yambiri, kusonyeza mphamvu zake pochiza kunenepa kwambiri, odwala omwe ali ndi T2DM komanso opanda T2DM."
Gulu la Mayo likukonzekera zolemba zina zingapo zokhudzana ndi semaglutide, kuphatikizapo zotsatira zolemera kwa odwala omwe anali ndi kulemera kwa thupi pambuyo pa opaleshoni ya bariatric;zotsatira zolemetsa kwa odwala omwe anali pamankhwala ena oletsa kunenepa kwambiri poyerekeza ndi omwe sanali.
Nthawi yotumiza: Sep-20-2023