Ndi coenzyme yamatsenga yomwe imapangitsa kuti matupi athu azigwedezeka.Umu ndi momwe NAD + imagwirira ntchito komanso chifukwa chake anthu ambiri amawona ngati njira yothanirana ndi ukalamba.
Pamene msika woletsa kukalamba ukuchulukirachulukira m’zaka zaposachedwapa, asayansi akhala akufufuza mankhwala alionse amene angachedwetse kapenanso kusintha kukalamba.Nthawi zambiri mayankho awo amakhala pakupeza zinthu zomwe zimasintha tikamakalamba, ndipo imodzi mwazofunikira kwambiri yakhala NAD +.Izi zawonetsedwa mu kuchuluka kwa zowonjezera zotsutsana ndi ukalamba zomwe zimafuna kupititsa patsogolo moyo wautali - koma mukangoyang'ana pansi pa hype pali chilichonse choti musangalale nacho?Izi ndi zomwe NAD+ ili, momwe imagwirira ntchito komanso chifukwa chake ili yofunika kwambiri mthupi lanu komanso thanzi lanu.
NAD+ ndi chiyani?
Pamene tikukalamba, thupi lathu limataya zinthu zina ndi mamolekyu omwe angakhale ofunika kuti tikhalebe achichepere.Imodzi mwa izi ndi nicotinamide adenine dinucleotide, yomwe imadziwika bwino kuti NAD+.
Asayansi adayamba kudziwa za kukhalapo kwa NAD + kumbuyo mu 1906. Kuyambira pamenepo, kumvetsetsa kwathu za izi kwakula pang'onopang'ono.Zapezeka molimbika pa ntchito m'maselo a anthu, nyama, zomera ngakhale yisiti kusunga chirichonse chikuyenda bwino.
NAD + ndi coenzyme yofunikira yomwe imapezeka mu cell iliyonse m'thupi lanu.Imagwira ntchito ziwiri zazikulu - kutembenuza zakudya kukhala mphamvu ndipo ndizofunikira kwambiri pamayendedwe a metabolic, ndikutumikira monga wothandizira pang'ono wochezeka pakuwongolera ntchito zina zama cell.
Imagwira bwino ntchito ngati chonyamulira chaching'ono chosuntha ma elekitironi kuchokera ku molekyulu kupita ku ina kuti ikwaniritse zochitika ndi njira zosiyanasiyana.Pamodzi ndi molekyu ina, NADH, imatenga nawo mbali pazochita zingapo zomwe zimapanga mphamvu m'maselo athu.Zimathandizanso kuwongolera kayimbidwe kathu ka circadian komwe kamayang'anira kugona kwathu / kudzuka.
Idapezeka koyamba mu 1906 ndiHarden ndi Youngmonga chigawo chimodzi kumapangitsanso mlingo wa mowa nayonso mphamvu mu yisiti akupanga.Kuyambira pamenepo, kumvetsetsa kwathu kwakula kwambiri, ndipo kwagwiritsidwa ntchito kulimbana ndi matenda angapo.
Chifukwa chiyani NAD + ndiyofunikira
NAD+ ndi chothandizira, kapena mafuta, a mamolekyu ena omwe amathandiza thupi kuchita bwino.Miyezo ikachepa, zochita za ma enzymes aliwonse odalira NAD (H) mu oxidative phosphorylation, TCA cycle, ndi glycolysis zimalephereka.
Izi zimabweretsa kuchepa kwa ATP.Zitha kukhudzanso magawo a PARP ndi ma sirtuins ndikupangitsa kuti njira zina zotsika za ma cell zomwe zimathandizira kukonza DNA.
Mwa kuyankhula kwina, popanda thupi lathu siligwira ntchito monga momwe lingathere, siligwira ntchito bwino pakudzikonza ndipo kumabweretsa kuchepa kwa kagayidwe kachakudya.Popanda NAD + kukhala ngati taxi yaying'ono yofunikira, maselo anu amatulutsa mphamvu zochepa zomwe thupi limafunikira kuti likhale ndi moyo ndikugwira ntchito zake.
Kufunika kwa NAD +, chifukwa chake, sikuchokera kuzinthu zamatsenga, koma kuthekera kwake kuthandiza mamolekyu ena opindulitsa kuchita ntchito zawo.Tikadakhala tikuwona thupi ngati timu ya mpira, NAD + ingakhale osewera wapakati, kupanga ma tackles ndikupereka zomwe zimathandiza oponya mpira kuyika mpira muukonde.
Sizowoneka bwino, sizowoneka bwino koma popanda izo, ntchito yonseyo imagwa.Mamolekyu omwe ndi ofunikira kukonzanso ma cell, kukonza kagayidwe kathu ndikuwongolera magwiridwe antchito achilengedwe.Popanda izo titha kukhala ndi akuchuluka kwa matenda.
Ubwino wamaganizidwe wamankhwala a NAD +
Chimodzi mwa zizindikiro za ukalamba ndi kuwonongeka kwa chidziwitso.Mumakonda kuiwala zinthu, kukhala ndi vuto lokhazikika, ndipo mumamva ngati ubongo wanu uli ndi mitambo kapena chifunga.Thandizo la NAD limalowa m'malo mwa coenzyme yofunikira kuti muchepetse kapena kuyimitsa kupitilira kwa kuchepa uku.Mudzakhala ndi:
- Kuwonjezeka m'maganizo
- Kukumbukira bwino
- Kukhazikika kwakukulu
- Makhalidwe abwino
- Maluso abwino othetsa mavuto
Kuwonjezeka kwa ntchito yaubongo komwe mumapeza kuchokera kumankhwala a NAD kumatha kukuthandizani kuthana ndi zovuta zamaganizidwe monga kukhumudwa, nkhawa, ndi zovuta zina zamaganizidwe.
Ubwino wakuthupi wamankhwala a NAD +
NAD nthawi zina imatchedwa "molekyu wothandizira" chifukwa imamangiriza ndi ma enzyme ena ndikuwathandiza kuti azichita bwino ntchito yawo.Zomwe zimachitika m'maselo anu zimapanga kusiyana kwakukulu momwe mumawonekera komanso momwe mumamvera.Mndandanda wamapindu amthupi kuchokera kumankhwala a NAD ndiwatali, ndipo chilichonse mwazosinthazi chingasinthe moyo wanu kukhala wabwino.
- Imalimbitsa thanzi la mtima
- Imawonjezera mphamvu
- Amawonjezera metabolism
- Amachepetsa kutupa
- Imafulumira kuchira kuvulala
- Amachepetsa ululu
- Imanola maso
- Kumamva bwino
- Amachepetsa chilakolako cha zinthu zoipa
- Amachepetsa zizindikiro za kusiya
- Imathandiza kuchepetsa thupi
- Amateteza mitsempha
- Amachepetsa ukalamba
Mwachiwonekere, phindu la chithandizo cha NAD likuyimira kupititsa patsogolo thanzi lanu lonse, komanso kusintha zizindikiro za matenda aakulu.
Maphunzirokuwonetsa kuti chithandizo cha NAD chimatha kuchepetsa zizindikiro za matenda a Alzheimer's.Ngakhale chomwe chimayambitsa matenda a Alzheimer sichidziwikabe, tikudziwa kuti chimakhudza kufa kwa maselo komanso kusagwira bwino ntchito kwa mitochondrial, zonse zomwe NAD imalankhula.Kuphatikiza apo, katundu wa NAD wa neuroprotective atha kuthandiza kupewa izi poyambira.
Nthawi yotumiza: Sep-21-2023